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Insight into membraneless organelles and their associated proteins: Drivers, Clients and Regulators
(Elsevier, 2021-06)
In recent years, attention has been devoted to proteins forming immiscible liquid phases within the liquid intracellular medium, commonly referred to as membraneless organelles (MLO). These organelles enable the spatiotemporal ...
Processing bodies oscillate in neuro 2A cells
(Frontiers Media S.A., 2019-10)
Circadian rhythms are biological variables that oscillate with periods close to 24 h that are generated internally by biological clocks. Depending on the tissue/cell type, about 5–20% of genes are expressed rhythmically. ...
Dynamics and functional relevance of ribonucleoproteic membrane-less organelles
(Tech Science Press, 2020)
The dynamic formation of stress granules (SGs), processing bodies (PBs) and related RNA membrane-less organelles, regulates diverse cellular processes, including the coordination of functionally linked messengers, and the ...
Unraveling the molecular interactions involved in phase separation of glucocorticoid receptor
(BioMed Central, 2020-06)
Background: Functional compartmentalization has emerged as an important factor modulating the kinetics and specificity of biochemical reactions in the nucleus, including those involved in transcriptional regulation. The ...
Smaug membraneless organelles regulate mitochondrial function
(Cold Spring Harbor Laboratory, 2020-07-31)
Smaug is a conserved translational repressor that recognizes specific RNA motifs in a large number of mRNAs, including nuclear transcripts that encode mitochondrial enzymes. Smaug orthologs have been shown to form membraneless ...
Revealing RCOR2 as a regulatory component of nuclear speckles
(2021)
Background: Nuclear processes such as transcription and RNA maturation can be impacted by subnuclear compartmentalization in condensates and nuclear bodies. Here, we characterize the nature of nuclear granules formed by ...
Life and Work of Stress Granules and Processing Bodies: New Insights into Their Formation and Function
(American Chemical Society, 2018-05)
The dynamic formation of stress granules (SGs), processing bodies (PBs), and related RNA organelles regulates diverse cellular processes, including the coordination of functionally connected messengers, the translational ...
Deconstructing virus condensation
(Public Library of Science, 2021-10)
Viruses have evolved precise mechanisms for using the cellular physiological pathways for their perpetuation. These virus-driven biochemical events must be separated in space and time from those of the host cell. In recent ...